Table 3.
Discrimination and calibration statistics for chronic kidney diseases risk model performance in subgroups of participants by gender, age and body mass index (BMI); for the outcome of CKD based on MDRD equation predicted glomerular filtration rate with or without proteinuria
| Models (outcome) | Men | Women | Age < 60 years | Age ≥ 60 years | BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | |
|---|---|---|---|---|---|---|---|
| Thai model (eGFR < 60 ml/min/1.73 m2) | E/O (95 % CI) | 1.49 (1.10-2.02) | 0.88 (0.77-1.00) | 1.13 (0.90-1.42) | 0.91 (0.79-1.05) | 0.98 (0.76-1.26) | 0.98 (0.85-1.12) |
| Brier score | 0.127 | 0.177 | 0.121 | 0.238 | 0.128 | 0.180 | |
| Yates slope | 0.267 | 0.190 | 0.0.032 | 0.083 | 0.259 | 0.175 | |
| C-statistic (95 % CI) | 0.834 (0.770-0.899) | 0.752 (0.714-0.790) | 0.608 (0.550-0.666) | 0.626 (0.567-0.685 | 0.854 (0.802-0.906) | 0.723 (0.681-0.765) | |
| Korean model (eGFR < 60 ml/min/1.73 m2) | E/O (95 % CI) | 0.99 (0.73-1.34) | 0.72 (0.63-0.82) | 0.68 (0.54-0.85) | 0.80 (0.69-0.92) | 0.75 (0.59-0.97) | 0.76 (0.66-0.88) |
| Brier score | 0.112 | 0.179 | 0.116 | 0.243 | 0.129 | 0.177 | |
| Yates slope | 0.246 | 0.199 | 0.049 | 0.087 | 0.259 | 0.186 | |
| C-statistic (95 % CI) | 0.856 (0.792-0.920) | 0.784 (0.747-0.821) | 0.678 (0.615-0.741) | 0.668 (0.610-0.726) | 0.869 (0.814-0.923) | 0.766 (0.727-0.806) | |
| Thai model (eGFR < 60 ml/min/1.73 m2 or proteinuria) | E/O (95 % CI) | 1.53 (1.13-2.08) | 0.87 (0.76-0.99) | 1.15 (0.92-1.43) | 0.89 (0.78-1.03) | 0.96 (0.75-1.23) | 0.97 (0.85-1.12) |
| Brier score | 0.127 | 0.175 | 0.123 | 0.233 | 0.125 | 0.179 | |
| Yates slope | 0.267 | 0.205 | 0.040 | 0.092 | 0.276 | 0.184 | |
| C-statistic (95 % CI) | 0.834 (0.770-0.899) | 0.768 (0.732-0.805) | 0.619 (0.561-0.676) | 0.646 (0.587-0.704) | 0.870 (0.821-0.919) | 0.734 (0.693-0.775) | |
| Korean mdel (eGFR < 60 ml/min/1.73 m2 or proteinuria) | E/O (95 % CI) | 1.02 (0.75-1.38) | 0.71 (0.62-0.80) | 0.69 (0.55-0.86) | 0.78 (0.68-0.91) | 0.74 (0.58-0.95) | 0.76 (0.66-0.87) |
| Brier score | 0.112 | 0.176 | 0.116 | 0.235 | 0.125 | 0.175 | |
| Yates slope | 0.246 | 0.219 | 0.059 | 0.104 | 0.284 | 0.201 | |
| C-statistic (95 % CI) | 0.856 (0.792-0.920) | 0.801 (0.766-0.836) | 0.689 (0.626-0.751) | 0.696 (0.640-0.753) | 0.886 (0.834-0.937) | 0.778 (0.740-0.817) |
eGFR, estimated glomerular filtration rate; E/O, Expected/Observed event rate; 95 % CI: 95 % confidence interval