Table 3.

Biomarker levels at exacerbation and 4 weeks follow-up

	Exacerbation (ng/ml)	Follow-up (ng/ml)	P value
C3M	29.24 [26.32–32.49]	22.64 [20.78–24.67]	<0.0001
C4M	95.96 [85.83–107.28]	73.30 [66.59–80.69]	<0.0001
C6M	19.78 [16.82–23.27]	13.27 [11.56–15.23]	<0.0001
ELM7	4.26 [3.90–4.64]	3.61 [3.37–3.87]	<0.0001
EL-NE	7.79 [6.30–9.63]	5.23 [4.41–6.21]	<0.0001
VCANM	1.69 [1.58–1.80]	1.87 [1.78–1.97]	0.0001
Pro-C3	12.10 [10.60–13.81]	12.79 [11.35–14.42]	0.2549
P4NP 7S	510.99 [440.91–592.21]	359.20 [312.28–413.17]	<0.0001
Pro-C6	5.36 [4.81–5.99]	6.38 [5.71–7.14]	<0.0001

Results are presented as geometric mean [95 % confidence interval] and corresponding P values comparing circulating biomarker levels at time of exacerbation and follow-up