Table 1.
Patient characteristics and indicators of nutritional status and inflammation in an international European cohort of 37,345 hemodialysis patients
| Characteristic | All (N=37,345) | LTI<10th Percentile, FTI<10th Percentile (n=1586) | LTI<10th Percentile, FTI 10th–90th Percentile (n=14,608) | LTI<10th Percentile, FTI>90th Percentile (n=1309) | LTI 10th–90th Percentile, FTI<10th Percentile (n=4855) | LTI 10th–90th Percentile, FTI 10th–90th Percentile (n=12,776) | LTI 10th–90th Percentile, FTI>90th Percentile (n=532) | LTI>90th Percentile, FTI<10th Percentile (n=874) | LTI>90th Percentile, FTI 10th–90th Percentile (n=769) | LTI>90th Percentile, FTI>90th Percentile (n=36) | P Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (y) | 62.7±15.2 | 62.2±13.0 | 61.5±15.1 | 58.8±14.6 | 63.3±15.6 | 64.0±15.4 | 59.1±14.0 | 67.3±14.6 | 65.4±13.5 | 61.0±10.0 | <0.001 |
| Vintage (y) | 2.8 (0.7–6.1) | 2.8 (0.5–7.2) | 3.1 (0.9–6.8) | 2.4 (0.9–4.9) | 2.6 (0.4–6.4) | 2.5 (0.7–5.4) | 2.1 (0.7–4.5) | 2.5 (0.5–5.8) | 2.4 (0.5–4.7) | 1.5 (0.7–3.5) | <0.001 |
| BMI (kg/m2) | 26.0±5.3 | 19.0±1.9 | 25.4±3.9 | 36.3±5.0 | 21.2±2.3 | 27.6±4.0 | 40.3±4.4 | 23.9±3.2 | 31.6±4.8 | 48.0±6.4 | <0.001 |
| Men (%) | 57±49 | 72±45 | 64±48 | 61±49 | 60±49 | 51±50 | 40±49 | 43±49 | 26±44 | 19±40 | <0.001 |
| Diabetic (%) | 24±43 | 17±37 | 28±45 | 42±49 | 13±34 | 23±42 | 37±48 | 16±36 | 29±45 | 39±49 | <0.001 |
| Fat mass (kg) | 26.1±11.7 | 14.0±4.1 | 28.8±8.7 | 52.0±10.2 | 12.7±4.6 | 27.0±8.3 | 52.3±8.9 | 10.2±5.0 | 26.5±8.0 | 55.4±10.9 | <0.001 |
| Lean tissue mass (kg) | 34.4±10.5 | 32.0±7.3 | 29.7±8.6 | 27.4±9.5 | 39.6±9.3 | 36.9±9.9 | 36.2±10.3 | 48.8±11.5 | 45.4±10.8 | 45.2±12.1 | <0.001 |
| Albumin (g/dl) | 3.8±0.4 | 3.6±0.5 | 3.8±0.4 | 3.8±0.4 | 3.8±0.5 | 3.9±0.4 | 3.9±0.4 | 3.7±0.5 | 3.8±0.5 | 4.1±0.4 | <0.001 |
| CRP (mg/L) | 6.0 (2.5–15) | 7.8 (2.4–21.6) | 6.7 (2.8–16.9) | 9.5 (4–19.7) | 4.6 (1.6–12.0) | 5.5 (2.3–12.7) | 9.9 (5–17.7) | 5 (2.1–13.2) | 7.0 (3.1–14.8) | 10.3 (3.3–16.6) | <0.001 |
| Creatinine (mg/dl) | 7.7±2.5 | 6.8±2.0 | 7.6±2.4 | 7.9±2.5 | 7.6±2.4 | 8.0±2.6 | 8.0±2.7 | 7.4±2.4 | 7.5±2.6 | 8.5±3.0 | <0.001 |
| Total cholesterol (mg/dl) | 172.0±44.0 | 164.6±41.9 | 169.6±44.2 | 177.0±46.6 | 167.1±40.4 | 175.5±43.9 | 179.3±38.3 | 174.5±46.4 | 187.3±52.2 | 168.7±40.0 | <0.001 |
| HDL cholesterol (mg/dl) | 42.1±14.6 | 45.9±16.1 | 41.2±14.8 | 39.1±14.4 | 46.1±15.0 | 41.5±13.8 | 36.4±10.1 | 46.8±16.2 | 41.7±14.0 | 38.6±11.3 | <0.001 |
| LDL cholesterol (mg/dl) | 100.3±37.6 | 94.7±34.4 | 99.3±37.6 | 101.4±39.0 | 97.9±35.2 | 102.2±38.2 | 105.2±39.1 | 97.9±38.3 | 109.7±38.4 | 97.0±36.1 | <0.001 |
| Triglycerides (mg/dl) | 161.8±99.4 | 121.9±62.9 | 159.992.3 | 200.6±120.3 | 123.3±67.0 | 174.8±107.9 | 224.2±134.0 | 149.9±103.3 | 191.6±122.3 | 240.1±102.1 | <0.001 |
| Predialysis systolic BP (mmHg) | 136.4±19.5 | 137.2±20.5 | 134.8±20.4 | 134.6±20.8 | 139.3±18.4 | 137.0±18.5 | 137.5±19.2 | 138.5±18.7 | 138.7±18.0 | 128.6±15.7 | <0.001 |
| Serum sodium (mmol/L) | 137.9±3.4 | 137.5±3.5 | 137.7±3.5 | 137.8±3.4 | 138.1±3.5 | 138.2±3.3 | 138.2±3.3 | 138.4±3.3 | 138.3±3.3 | 139.4±3.4 | <0.001 |
| Body surface area (m2) | 1.8±0.2 | 1.6±0.2 | 1.8±0.2 | 2.0±0.2 | 1.6±0.2 | 1.8±0.2 | 2.1±0.2 | 1.7±0.2 | 1.8±0.2 | 2.1±0.3 | <0.001 |
| FTI (kg/m2) | 9.8±4.5 | 5.1±1.5 | 10.6±3.4 | 19.6±4.2 | 4.7±1.7 | 10.2±9.3 | 20.2±3.9 | 3.9±1.9 | 10.5±3.2 | 22.8±4.3 | <0.001 |
| LTI (kg/m2) | 12.5±3.1 | 11.4±1.9 | 10.7±2.3 | 10.0±2.6 | 14.4±2.4 | 13.6±2.5 | 13.6±2.4 | 18.4±3.0 | 17.7±3.2 | 18.3±3.0 | <0.001 |
| Died (%) | 9±29 | 17±40 | 10±30 | 9±28 | 10±30 | 7±25 | 7±26 | 10±30 | 9±28 | 8±28 |
Values are mean baseline values±SDs. Median baseline values (interquartile range) are reported for CRP and dialysis vintage (25th–75th percentiles). Baseline was defined as the first BCM Body Composition Monitor measurement available for a patient in the study period (April 1, 2006–December 31, 2012), whereby all other values were averaged for the period ±30 days of the first BCM Body Composition Monitor measurement. P values were estimated with one-way ANOVA (standard with Gaussian assumption or Kruskal–Wallis test). BMI, body mass index; CRP, C-reactive protein; FTI, fat tissue index; LTI, lean tissue index.