Table 3.
Results of Cox proportional-hazards models
| Model | Models Adjusted for Age, Vintage, and Sex | Fully Adjusted Modelsa | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% LCI | 95% UCI | P Value | HR | 95% LCI | 95% UCI | P Value | |
| Model 1: LTI without FTI | ||||||||
| Low LTI | 1.68 | 1.56 | 1.80 | <0.001 | 1.53 | 1.40 | 1.66 | <0.001 |
| Normal LTI (reference) | ||||||||
| High LTI | 1.20 | 1.01 | 1.41 | 0.03 | 1.02 | 0.84 | 1.24 | 0.85 |
| Model 2: FTI without LTI | ||||||||
| Low FTI | 1.34 | 1.24 | 1.45 | <0.001 | 1.19 | 1.08 | 1.31 | <0.001 |
| Normal FTI (reference) | ||||||||
| High FTI | 1.19 | 1.01 | 1.40 | 0.03 | 1.23 | 1.02 | 1.47 | 0.03 |
| Model 3: LTI and FTI combined | ||||||||
| Low LTI, low FTI | 3.37 | 2.94 | 3.87 | <0.001 | 2.51 | 2.12 | 2.96 | <0.001 |
| Low LTI, normal FTI | 1.81 | 1.67 | 1.97 | <0.001 | 1.63 | 1.48 | 1.81 | <0.001 |
| Low LTI, high FTI | 1.79 | 1.47 | 2.17 | <0.001 | 1.74 | 1.40 | 2.17 | <0.001 |
| Normal LTI, low FTI | 1.57 | 1.40 | 1.75 | <0.001 | 1.42 | 1.25 | 1.62 | <0.001 |
| Normal LTI, normal FTI (reference) | ||||||||
| Normal LTI, high FTI | 1.36 | 0.99 | 1.89 | 0.06 | 1.41 | 0.99 | 2.01 | 0.06 |
| High LTI, low FTI | 1.42 | 1.14 | 1.76 | 0.002 | 0.99 | 0.75 | 1.32 | 0.95 |
| High LTI, normal FTI | 1.28 | 1.00 | 1.64 | 0.05 | 1.31 | 1.00 | 1.73 | 0.05 |
| High LTI, high FTI | 1.73 | 0.56 | 5.38 | 0.34 | 1.91 | 0.48 | 7.65 | 0.36 |
Outcome was all-cause mortality; predictors were categories of low (<10th percentile) and high (>90th percentile) LTI and FTI, respectively. Models were adjusted for age, vintage, and sex or as otherwise indicated. LTI, lean tissue index; FTI, fat tissue index; reference, normal LTI and FTI (10th–90th percentile of age- and sex-matched healthy population); HR, hazard ratio; 95% LCI, lower 95% confidence interval; 95% UCI; upper 95% confidence interval.
a
Adjusted for age, vintage, sex, geographic region, albumin, hemoglobin, diabetes, and BP.