Fig. 1.

Body weight gain (a), body fat gain (b) and mRNA expression levels of Leptin (c) and Mest/Peg1 (d) in epididymal white adipose tissue (eWAT) of mice fed semi-synthetic low-fat diet (LF), or high-fat diet (HF) or a HF diet with different anti-obesity interventions for 5 days. HF + EGCG: supplementation with 0.5 % w/w epigallocatechin gallate (EGCG); HF + EPAX: replacement of 15 % of dietary lipids by n-3 LC-PUFA (EPAX1050); HF/HP: high-protein diet, partial replacement of carbohydrates by casein to achieve 43 energy% of protein. Data are means + SEM (n = 7–10). Significant differences between groups were tested by one-way ANOVA and least-significant difference (LSD) post hoc comparisons (P < 0.05). Values not sharing a common letter are statistically different