Table 1.
Characteristics of the lumbar vertebra
| Sham | OVX | 1.1 μg/kg teriparatide |
5.6 μg/kg teriparatide |
28.2 μg/kg teriparatide |
|
|---|---|---|---|---|---|
| n | 12 | 15 | 15 | 15 | 13 |
| DXA | |||||
| BMC (mg) | 17.1 ± 2.6 | 10.6 ± 1.4†† | 12.3 ± 1.5* | 17.4 ± 1.9** | 18.9 ± 2.5** |
| BMD (mg/cm2) | 63.1 ± 7.5 | 44.2 ± 3.9†† | 49.0 ± 3.8* | 62.7 ± 6.0** | 68.8 ± 7.1** |
| Micro-CT | |||||
| Trabecular bone | |||||
| BV/TV (%) | 35.4 ± 4.4 | 16.2 ± 3.3†† | 22.1 ± 2.7* | 34.1 ± 6.6** | 41.6 ± 8.2** |
| Tb.Th (μm) | 86 ± 6 | 87 ± 8 | 92 ± 9 | 107 ± 7** | 110 ± 8** |
| Tb.N (1/mm) | 2.34 ± 0.15 | 1.27 ± 0.26†† | 1.50 ± 0.15* | 1.73 ± 0.27** | 1.89 ± 0.26** |
| TBPf (1/mm) | −1.97 ± 1.87 | 4.20 ± 2.21†† | 0.61 ± 1.39** | −3.04 ± 1.84** | −5.67 ± 2.38** |
| SMI | 0.50 ± 0.27 | 1.63 ± 0.43†† | 1.16 ± 0.27* | 0.59 ± 0.47** | −0.01 ± 0.66** |
| Mechanical properties (compressive test) | |||||
| Maximum load (N) | 336 ± 68 | 220 ± 38†† | 265 ± 45 | 419 ± 65** | 485 ± 101** |
| Stiffness (N/mm) | 2152 ± 316 | 1787 ± 275†† | 1887 ± 352 | 2338 ± 248** | 2298 ± 237** |
| Energy (N·mm) | 32.2 ± 9.5 | 18.0 ± 4.2†† | 24.0 ± 5.1 | 46.5 ± 11.2** | 63.6 ± 20.8** |
Values are shown as means ± SD
Sham sham surgery, OVX ovariectomy, BMC bone mineral content, BMD bone mineral density, BV/TV cancellous bone volume/tissue volume, Tb.Th trabecular thickness, Tb.N trabecular number, TBPf trabecular bone pattern factor, SMI structure model index
* P < 0.05 and ** P < 0.01: teriparatide versus OVX (Williams’ test for bone density and mechanical properties; Dunnett’s test for micro-CT); †† P < 0.01: OVX versus sham (t test)