Table 2.
Characteristics of the proximal femur
| Sham | OVX | 1.1 μg/kg teriparatide |
5.6 μg/kg teriparatide |
28.2 μg/kg teriparatide |
|
|---|---|---|---|---|---|
| n | 12 | 15 | 15 | 15 | 13 |
| DXA | |||||
| BMC (mg) | 147 ± 16 | 124 ± 10†† | 123 ± 7 | 148 ± 14** | 160 ± 15** |
| BMD (mg/cm2) | 140 ± 10 | 119 ± 6†† | 121 ± 5 | 140 ± 8** | 150 ± 8** |
| Micro-CT | |||||
| Femoral neck | |||||
| Trabecular bone | |||||
| BV/TV (%) | 65.3 ± 6.7 | 43.2 ± 14.7†† | 48.3 ± 10.5 | 71.6 ± 15.3** | 89.6 ± 10.3** |
| Tb.Th (μm) | 129 ± 14 | 125 ± 20 | 129 ± 14 | 158 ± 29** | 167 ± 36** |
| Tb.N (1/mm) | 2.01 ± 0.49 | 1.89 ± 0.98 | 1.94 ± 0.48 | 2.54 ± 0.74 | 3.22 ± 0.96** |
| TBPf (1/mm) | −9.0 ± 2.1 | −2.8 ± 3.2†† | −5.2 ± 2.2 | −10.9 ± 5.0** | −17.8 ± 6.2** |
| SMI | 1.57 ± 0.20 | 2.310 ± 0.30†† | 2.23 ± 0.25 | 2.10 ± 0.40 | 2.24 ± 0.42 |
| Cortical bone | |||||
| Cv/Av (%) | 78.5 ± 4.4 | 81.8 ± 7.4 | 84.5 ± 5.6 | 86.0 ± 5.5 | 90.1 ± 3.6** |
| Ct.Th (μm) | 552 ± 37 | 576 ± 54 | 597 ± 40 | 639 ± 57** | 703 ± 61** |
| Ex.L (mm) | 6.96 ± 0.39 | 6.69 ± 0.52 | 6.58 ± 0.35 | 6.77 ± 0.32 | 6.74 ± 0.39 |
| In.L (mm) | 3.29 ± 0.49 | 2.98 ± 0.82 | 2.73 ± 0.56 | 2.65 ± 0.61 | 2.20 ± 0.46** |
| Vv/Cv (%) | 0.2 ± 0.1 | 0.2 ± 0.4 | 0.1 ± 0.1 | 0.1 ± 0.2 | 0.3 ± 0.7 |
| Femoral intra-trochanter | |||||
| Trabecular bone | |||||
| BV/TV (%) | 43.5 ± 5.8 | 22.7 ± 6.0†† | 28.3 ± 3.3 | 43.1 ± 7.0** | 50.8 ± 8.3** |
| Tb.Th (μm) | 123 ± 11 | 114 ± 7†† | 110 ± 8 | 121 ± 9* | 129 ± 9** |
| Tb.N (1/mm) | 1.06 ± 0.16 | 0.70 ± 0.22†† | 0.78 ± 0.13 | 0.99 ± 0.18** | 1.17 ± 0.24** |
| TBPf (1/mm) | −4.49 ± 1.78 | 1.37 ± 1.50†† | −1.67 ± 1.10** | −4.33 ± 1.39** | −5.19 ± 1.92** |
| SMI | 1.21 ± 0.21 | 1.93 ± 0.19†† | 1.55 ± 0.15* | 1.25 ± 0.18** | 1.2 ± 0.28** |
| Cortical bone | |||||
| Cv/Av (%) | 49.4 ± 2.3 | 44.3 ± 3.0†† | 45.9 ± 2.7 | 50.6 ± 2.8** | 55.8 ± 3.0** |
| Ct.Th (μm) | 650 ± 40 | 579 ± 50†† | 592 ± 43 | 680 ± 45** | 758 ± 49** |
| Ex.L (mm) | 17.8 ± 0.6 | 18.0 ± 0.6 | 17.7 ± 0.4 | 18.1 ± 0.6 | 17.9 ± 0.6 |
| In.L (mm) | 12.7 ± 0.5 | 13.4 ± 0.4†† | 12.9 ± 0.4* | 12.7 ± 0.5** | 11.9 ± 0.5** |
| Vv/Cv (%) | 2.1 ± 0.5 | 4.5 ± 1.5†† | 3.8 ± 0.6 | 3.3 ± 1.1* | 2.3 ± 0.6** |
| Mechanical properties | |||||
| Maximum load (N) | 117 ± 23 | 106 ± 13†† | 110 ± 15 | 125 ± 21** | 130 ± 24** |
| Stiffness (N/mm) | 514 ± 109 | 448 ± 59 | 461 ± 63 | 521 ± 56** | 546 ± 53** |
| Energy (N·mm) | 16.2 ± 3.9 | 17.0 ± 4.1 | 16.6 ± 3.5 | 17.9 ± 5.1 | 18.2 ± 5.2 |
Values are shown as means ± SD
Sham sham surgery, OVX ovariectomy, BMC bone mineral content, BMD bone mineral density, BV/TV cancellous bone volume/tissue volume, Tb.Th trabecular thickness, Tb.N trabecular number, TBPf trabecular bone pattern factor, SMI structure model index, Cv/Av cortical bone ratio, Ct.Th cortical bone thickness, Ex.L external length, In.L internal length, Vv/Cv cortical void volume
* P < 0.05 and ** P < 0.01: teriparatide versus OVX (Williams’ test for bone density and mechanical properties; Dunnett’s test for micro-CT); †† P < 0.01: OVX versus sham (t test)