Fig. 1.

Time-course of the changes in paracellular permeability of bEnd.3 cells after exposure to various concentrations of hypoglycemia during a 24-h period. bEnd.3 cells were plated in a monolayer with Na-F applied. Na-F was evaluated following treatment with 5.5 mM (control) or 0, 0.5, or 1 mM over 1, 3, 6, 12, and 24 h. Data are expressed as the percentage of the time-matched control value. Data are expressed as the mean ± SEM. N = 4. ^* P < 0.05, ^** P < 0.01