Table 3.
The predictive value of S-creatinine, S-creatinine ratio, and CCR for delayed MTX elimination.
| Parameters | AUC | P value | Cut-off | Sensitivity | Specificity |
|---|---|---|---|---|---|
| S-creatinine 24 h | 0.756 (0.672–0.840) | <0.001 | >35.0 | 68.6% | 70.1% |
| S-creatinine ratio 24 h | 0.759 (0.668–0.850) | <0.001 | >1.129 | 69.8% | 80.0% |
| CCR_24 h | 0.771 (0.688–0.854) | <0.001 | <100.0 | 68.6% | 74.1% |
| CCR ratio 24 h | 0.728 (0.626–0.829) | <0.001 | <0.824 | 67.4% | 73.1% |
| S-creatinine 0 h | 0.422 (0.324–0.519) | 0.130 | |||
| CCR_0 h | 0.509 (0.409–0.608) | 0.859 |
S-creatinine 24 h: serum creatinine level in 24 hours after MTX infusion; S-creatinine ratio 24 h: the ratio of serum creatinine level in 24 hours to creatinine level before MTX infusion; CCR_24 h: creatinine clearance rate in 24 hours after MTX infusion; CCR ratio 24 h: the ratio of CCR in 24 hours to CCR before MTX infusion; S-creatinine 0 h: serum creatinine level before MTX infusion; CCR_0 h: creatinine clearance rate before MTX infusion.