Table 1.

Clinicopathological associations of CRABP1 and CRABP2 in human breast cancers

	Factor	Classification	cDNA microarray			Tissue microarray
			n	Geometric mean	p	Cytoplasmic immunoreactivity					Nuclear immunoreactivity
						Negative		Positive		p	Negative		Positive		p
CRABP1	ER	Negative	64	4.16	<0.0001	20		21		0.0058	28		13		0.0583
		Positive	112	0.67		49		15			54		10
	PR	Negative	82	2.80	<0.0001	27		25		0.0040	37		15		0.1031
		Positive	94	0.67		42		11			45		8
	Her2	Negative	146	1.39	0.2038	53		31		0.3119	63		21		0.1512
		Positive	30	0.94		16		5			19		2
	Triple negative	No	120	0.72	<0.0001	52		17		0.0051	59		10		0.0142
		Yes	56	4.63		17		19			23		13
	Death	No	119	1.13	0.1641	49		18		0.0532	53		9		0.8078
		Yes	57	1.74		20		18			29		14
	Recurrence	No	88	1.21	0.6020	36		10		0.0225	39		7		0.1615
		Yes	88	1.40		33		26			43		16
	Nodal status	pN0	69	0.81	0.021	26		14		1.0000	31		9		1.0000
		pN1-3	107	1.21		42		22			51		14
	Cancer stage	I	45	1.63	0.1635	21		3		0.0133	22		2		0.0919
		II–III	131	1.21		48		33			60		21
	Nuclear grade	Low	44	0.34	<0.0001	20		4		0.0050	24		0		0.0015
		High	132	2.04		49		32			58		23
	Mitotic grade	Low	78	0.48	<0.0001	36		7		0.0016	41		2		0.0003
		High	98	2.91		33		29			41		21
	Arch grade	Low	29	0.76	0.0929	10		0		0.0145	10		0		0.1129
		High	147	1.45		59		36			72		23
	Overall grade	Low	56	0.41	<0.0001	25		5		0.0221	30		0		0.0002
		High	120	2.24		44		31			52		23
						Cytoplasmic immunoreactivity					Nuclear immunoreactivity
						0	1	2	3	p	0	1	2	3	p
CRABP2	ER	Negative	64	0.63	<0.0001	7	18	13	3	0.0613	5	11	13	12	0.0010
		Positive	112	1.37		3	29	19	14		0	6	25	34
	PR	Negative	82	0.73	0.0002	8	23	17	4	0.0371	5	12	19	16	0.0070
		Positive	94	1.40		2	24	15	13		0	5	19	30
	Her2	Negative	146	0.95	0.0369	9	39	24	13	0.6762	4	15	30	36	0.8405
		Positive	30	1.53		1	8	8	4		1	2	8	10
	Triple negative	No	120	1.32	p < 0.0001	4	30	22	14	0.1545	1	6	28	35	0.0019
		Yes	56	0.61		6	17	10	3		4	11	10	11
	Death	No	119	1.12	0.2089	4	34	21	9	0.1819	1	12	28	27	0.0843
		Yes	57	0.87		6	13	11	8		4	5	10	19
	Recurrence	No	88	1.02	0.8998	3	26	13	5	0.1837	1	11	18	17	0.1567
		Yes	88	1.04		7	21	19	12		4	6	20	29
	Nodal status	pN0	69	1.78	0.0819	4	20	14	3	0.2813	2	8	19	12	0.1308
		pN1-3	107	1.07		6	27	18	14		3	9	19	34
	Cancer stage	I	45	0.81	0.0895	3	13	7	2	0.5660	2	4	11	8	0.5062
		II–III	131	1.12		7	34	25	15		3	13	27	38
	Nuclear grade	Low	44	1.12	0.5981	1	12	7	4	0.7638	1	2	11	10	0.5616
		High	132	1.05		9	35	25	13		4	15	27	36
	Mitotic grade	Low	78	1.11	0.4743	2	19	13	10	0.2547	0	4	17	23	0.0618
		High	98	0.98		8	28	19	7		5	13	21	23
	Arch grade	Low	29	1.20	0.4399	1	6	3	1	0.8747	0	1	3	7	0.5014
		High	147	1.00		9	41	29	16		5	16	35	39
	Overall grade	Low	56	1.04	0.9369	1	15	10	5	0.5695	0	3	14	14	0.2344
		High	120	1.03		9	32	22	12		5	14	24	32