Table 5. Median CAC progression, expressed as CAC volume score, by source of premature family history.

Source of Premature Family History	Model 1		Model 2		Model 3
	β(95%CI) CAC Score	p value	β(95%CI) CAC Score	p value	β (95% CI) CAC Score	p value
No Family History	1 (Reference)		1 (Reference)		1 (Reference)
Parent	16.86(6.10-27.62)*	0.002	9.34 (-4.24-22.92)	0.18	2.64 (-9.59-14.88)	0.67
Sibling	23.39 (13.57-33.21)*	<0.001	16.98(4.74-29.22)*	0.007	8.37 (-2.79-19.53)	0.14
Parent and Sibling	37.17 (14.53-59.81)*	0.001	26.24(-1.98-54.47)	0.07	12.52 (-13.10-38.14)	0.34

^*indicates significance at the 0.05 level.

All analyses are in comparison to participants with no family history of CHD, which was the reference group. Model 1 adjusted for age, gender, race/ethnicity, MESA site, and follow-up duration. Model 2 adjusted age, gender, race/ethnicity, MESA site, follow-up duration, education, BMI, hypertension, diabetes mellitus, systolic blood pressure, anti-hypertensive medications, cigarette smoking, LDL-C, and HDL-C. Model 3 adjusted for age, gender, race/ethnicity, MESA site, follow-up duration, education, BMI, hypertension, diabetes mellitus, systolic blood pressure, anti-hypertensive medications, cigarette smoking, LDL-C, HDL-C, and the logarithm of baseline CAC score.