Table 4.
Relationship of genotype and mRNA expression (median, IQR; corrected for β-actin) by general genetic model (comparing expression in 3 genotypes: AA, Ab, bb) in IBS (analysis used ANOVA on ranks to compare 3 genotypes)
| Genotype | MAF | N | mRNA Expression | P |
|---|---|---|---|---|
| Serotonin transporter | ||||
| SLC6A4 rs4795541LL | 0.447 (L) | 7 | 16.59 (15.47, 17.44) | 0.463 |
| SLC6A4 rs4795541LS | 28 | 16.49 (15.19, 17.95) | ||
| SLC6A4 rs4795541SS | 12 | 15.72 (14.87, 16.75) | ||
| Immune function | ||||
| TNFSF15 rs4263839AA | 0.38 (A) | 6 | 12.94 (12.11, 13.85) | 0.27 |
| TNFSF15 rs4263839AG | 24 | 12.55 (12.11, 13.54) | ||
| TNFSF15 rs4263839GG | 17 | 12.28 (12.07, 12.96) | ||
| Bile acid absorption, homeostasis, or receptor | ||||
| GPBAR1 rs11554825CC | 0.436 (C) | 10 | 13.05 (12.53, 13.33) | 0.082 |
| GPBAR1 rs11554825CT | 21 | 12.86 (12.52, 13.03) | ||
| GPBAR1 rs11554825TT | 16 | 13.18 (12.72, 13.59) | ||
| NR1H4 rs17030285 CC | 0.128 (G) | 35 | 12.80 (11.59, 13.04) | 0.30 |
| NR1H4 rs17030285 CG | 12 | 11.83 (11.15, 12.46) | ||
| NR1H4 rs4764980 AA | 0.49 (G) | 12 | 12.30 (11.60, 12.75) | 0.98 |
| NR1H4 rs4764980 AG | 23 | 12.03 (11.09, 13.22) | ||
| NR1H4 rs4764980 GG | 12 | 12.18 (11.15, 12.93) | ||
| SLC10A2 rs188096 AC | 0.106 (A) | 10 | 16.65 (15.83, 17.80) | 0.82 |
| SLC10A2 rs188096 CC | 37 | 17.16 (15.11, 17.87) | ||
| FGFR4 rs1966265 AA | 0.213 (A) | 2 | 10.15 (9.55, 10.75) | 0.18 |
| FGFR4 rs1966265 AG | 16 | 11.06 (10.79, 11.32) | ||
| FGFR4 rs1966265 GG | 29 | 10.85 (10.46, 11.52) | ||
| FGFR4 rs434434 AG | 0.191 (A) | 18 | 10.80 (10.52, 11.11) | 0.28 |
| FGFR4 rs434434 GG | 29 | 11.03 (10.54, 11.52) | ||
| FGFR4 rs351855 AA | 0.287 (A) | 2 | 11.17 (10.51, 11.83) | 0.73 |
| FGFR4 rs351855 AG | 25 | 11.03 (10.51, 11.52) | ||
| FGFR4 rs351855 GG | 20 | 10.83 (10.62, 11.17) | ||
MAF, minor allele frequency.