Table 7.
Associations of variants in genes (associated with BA absorption and feedback regulation of synthesis) with serum FGF-19, serum C4, and 48-h fecal BA excretion in IBS-D
| Genotype | N | Fasting Serum FGF-19, pg/ml | P | Fasting Serum C4, ng/ml | P | Total Fecal BA, μmol/48 h | P |
|---|---|---|---|---|---|---|---|
| SLC10A2 rs188096 AC | 10 | 117 (63, 246) | 0.13 | 28 (16, 60) | 0.73 | 2723 (1037, 7766) | 0.25 |
| SLC10A2 rs188096 CC | 37 | 86 (47, 135) | 26 (14, 41) | 1827 (737, 2887) | |||
| KLB rs17618244 AG | 17 | 110 (55, 173) | 0.38 | 26 (13,54) | 0.99 | 2127 (1493, 4056) | 0.30 |
| KLB rs17618244 GG | 30 | 81 (48, 138) | 26 (15.5, 46) | 1559 (694, 3055) | |||
| FGFR4 rs351855GG | 20 | 74.2 (46.5, 157.8) | 0.45 | 39 (13,61) | 0.13 | 1850 (1073, 2916) | 0.87 |
| FGFR4 rs351855 AG/AA | 27 | 99.8 (57.7, 144.7) | 23 (16, 36) | 1829 (733, 3442) | |||
| FGFR4 rs1966265 GG | 29 | 94.3 (49.3, 154.2) | 1.00 | 27 (16, 59) | 0.37 | 2127 (903, 4543) | 0.16 |
| FGFR4 rs1966265AG/AA | 18 | 101.7 (49.1,140.1) | 23 (14, 38) | 1559 (666, 2741) | |||
| FGFR4 rs434434 GG | 29 | 77.9 (44.6, 132.8) | 0.11 | 26 (16, 38) | 0.92 | 1829 (676, 3652) | 0.99 |
| FGFR4 rs434434 GA | 18 | 107.2 (63.9,182.4) | 26 (12, 59) | 1890 (1078, 2894) |
Data show median and interquartile range.