Fig. 1.
Genetic activation of nuclear erythroid 2-related factor 2 (Nrf2) reduces ovalbumin (OVA)-induced asthmatic phenotypes. A: NADPH quinone oxidoreductase 1 (Nqo1) gene expression, as a marker of Nrf2 activity, was measured in lungs of Kelch ECH associating protein 1-floxed (Keap1fl/fl) and Tam-Keap1−/− mice that were treated with tamoxifen (Tam) before sensitization. These same mice were used in B–D. B: airway hyperresponsiveness (AHR) was assessed by airway pressure-time index (APTI) (cmH2O·s) after inhalation of methacholine. Inflammation (C) and cytokines (D) were quantified in the bronchoalveolar lavage (BAL). Values are means ± SE; N = 6–9 mice per group. *P < 0.05 by ANOVA.