Fig. 3.

Activation of Nrf2 in club cells attenuates OVA-induced asthmatic phenotypes. A: AHR was assessed by APTI (cmH₂O·s) in Keap1^fl/fl and club cell-specific 10-kDa protein (CC10)-Keap1^−/− mice in response to inhalation of methacholine. Inflammation (B) and cytokines (C) were quantified in the BAL. Values are means ± SE; N = 11–12 mice per group. *P < 0.05 by ANOVA. D: mucus secretion was assessed by periodic acid Schiff staining of airways from OVA-exposed Keap1^fl/fl and CC10-Keap1^−/− mice (N = 5 mice per group). Representative images were captured at ×40 (left) and ×200 (right) magnification.