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Fractional contributions of acetyl-CoA to the CAC by 13C-NMR. Fractional contribution (Fc) from [13C6,15N]-l-leucine did not change with pyruvate supplement during ECMO. Fc of [2-13C]-pyruvate was decreased in the unlabeled pyruvate infusion group, reflected by an increase in unlabeled substrate. Values are means ± SE; n = 6 per group, †P < 0.01.
