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FOXA2 regulates a network of genes that are biologically important for intestinal epithelial function. A: luciferase-based cAMP assay showing the levels of intracellular cAMP in Caco2 cells treated with Neg Cont or FOXA1/A2 siRNAs. The level of cAMP in cells treated with Neg Cont siRNA has been set to 1. RLU, relative light units. ***P < 0.001. B: RT-qPCR analysis of ADCY9 and ADCY10, other putative FOXA2 targets that could alter the levels of intracellular cAMP in cells. *P < 0.05.
