FIGURE 7.

ER α expression in the monkey dorsolateral PFC and its relationship to working memory. A: an electron micrograph shows ER α immunogold particles (blue arrowheads) in pre- and postsynaptic compartments. [Micrograph modified from Wang et al. (222).] B: ER α is abundantly expressed in monkey PFC synapses, and the proportion of ER α-containing synapses is not significantly altered with aging or estradiol (E2) treatment. Veh, vehicle-treated. [Histogram replotted from data presented in Wang et al. (222).] C: schematic diagrams illustrating that in aged E2-treated monkeys, the abundance of ER α in the postsynaptic density (PSD) correlates with working memory performance. [Diagrams drawn based on findings from Wang et al. (222).]