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. 2015 Apr 20;4(4):e147. doi: 10.1038/oncsis.2015.7

Figure 2.

Figure 2

(a) Test set. Time-dependent AUC plot of biomarkers improvement upon clinical parameters. The baseline model (dashed line) is fitted using age, gender, site, histology grade, nodal status, clinical stage and tumor stage. The biomarkers considered were nuclear S100A7, cytoplasmic hnRNPK, nuclear PTMA and cytoplasmic PTMA. The improved baseline model (solid line) was fitted using clinical parameters extended by the biomarker signature score. (b). Validation set. Time-dependent AUC plot of biomarkers improvement upon clinical parameters. The baseline model (dashed line) is fitted using age, gender, site, histology grade, nodal status, clinical stage and tumor stage. The biomarkers considered were nuclear S100A7, cytoplasmic hnRNPK, nuclear PTMA and cytoplasmic PTMA. The improved baseline model (solid line) was fitted using clinical parameters extended by the biomarker signature score.