Table 1. Immunohistochemical analysis of five biomarkers in normal oral tissues and OSCCs within test and validation sets.
| Clinical features | Test set | Validation set |
|---|---|---|
| Normal | 209 | 96 |
| Cancer | 282 | 135 |
| Age (years)a | 49 (38,60) | 63 (53,74) |
| Gender | ||
| Female | 70 (33%) | 52 (39%) |
| Male | 212 (67%) | 83 (61%) |
| Site | ||
| Alveolus | 39 (14%) | 2 (1.5%) |
| BM | 108 (38%) | 14 (10%) |
| Mandible | 4 (1%) | 8 (6%) |
| Lip | 6 (2%) | 1 (1.5%) |
| Palate | 8 (3%) | 2 (1%) |
| RMT | 10 (4%) | 0 (0%) |
| Tongue | 98 (35%) | 108 (80%) |
| Others | 9 (3%) | 0 (0%) |
| HP grade | ||
| WDSCC | 166 (59%) | 33 (25%) |
| MDSCC | 106 (37%) | 87 (64%) |
| PDSCC | 10 (4%) | 15 (11%) |
| T stage | ||
| T1 and T2 | 77 (27%) | 102 (75%) |
| T3 and T4 | 205 (73%) | 33 (25%) |
| Node | ||
| N− | 99 (35%) | 76 (56%) |
| N+ | 183 (65%) | 59 (44%) |
| Clinical stage | ||
| I and II | 33 (12%) | 62 (46%) |
| III and IV | 249 (88%) | 73 (54%) |
| Biomarker risk scorea | 12 (6.3, 17) | 11 (9.0, 15) |
Abbreviations: BM, buccal mucosa; HP grade, histopathological grade; RMT, retro molar trigone; T stage, tumor stage.
a
Median (25th and 75th percentiles).