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. 2015 Jun 15;4(6):e159. doi: 10.1038/oncsis.2015.10

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Copyright © 2015 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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DCTPP1 promotes mammosphere formation in breast cancer cells. (a) Mammospheres from NC-shRNA-transfected MCF-7 and two DCTPP1-shRNA-transfected MCF-7 cells were observed under light microscope with × 100 magnification (Scale bar, 200 μm; left panel). The sphere formation percentage was calculated from randomly selected eight fields and analyzed by Graphpad Prism 6 (right panel). (b) Mammospheres from DCTPP1 overexpressing and control MDA-MB-231 cells were observed at day 5 after conditional induction. The spheres markedly enlarged with DCTPP1 overexpression (left panel). The sphere formation percentages were calculated from randomly selected eight fields and analyzed by Graphpad Prism 6 (right panel). The transcription factors related to CSC properties were measured by real-time PCR as well as DCTPP1 in DCTPP1-deficient MCF-7 (c) and DCTPP1 overexpressing MDA-MB-231 cells (d). (***P⩽0.001, ** P⩽0.01)