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. 2015 Jul 6;6:149. doi: 10.3389/fneur.2015.00149

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Copyright © 2015 Seebohm, Piccini and Strutz-Seebohm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chimeric and homology modeling/docking approach to identify and simulate autoantibody-target protein interaction. (A) Construction of a chimera of closely related target proteins but with different autoantibody binding affinities can help to identify epitope regions in the target protein. Complementary gain-of-function and loss-of-functional approaches provide evidence for the location of the interaction region. (B) Models of the target (GluN1) and the specific IgG can be generated based on solved highly homologous crystal structural coordinates. Docking of the interaction partner in the region of the experimentally determined epitope site allows for analysis of structural effects in silico.