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The threshold intensity to block nerve conduction changes with the stimulation frequency. (A) For the symmetric waveform, the block threshold monotonically increases as the frequency increases. (B) If the positive pulse is longer (1 or 2 μs), the block threshold peaks at 60–80 kHz and then gradually decreases as the frequency increases. (C) If the negative pulse is longer (1 or 2 μs), the block threshold peaks at 40–70 kHz. Axon diameter: 2 μm.
