Table 2.
HCV load, tryptophan, kynurenine, nitrite and neopterin concentrations as well as the kynurenine to tryptophan ratio (KYN/TRP) in patients with HCV infection grouped according to IL-28B polymorphisms (mean ± S.D. are shown; n.s. = not significant).
| IL28B Polymorphism | C/C | C/T | T/T | non-C/C | Χ2, p * | U, p ** |
|---|---|---|---|---|---|---|
| (n = 8) | (n = 5) | (n = 12) | (n = 17) | |||
| HCV load [log 10 copies/µL] | 5.56 ± 1.38 | 5.87 ± 0.92 | 5.63 ± 0.73 | 5.80 ± 0.85 | 0.183, n.s. | 0.146, n.s. |
| Age [y] | 49.1 ± 13.6 | 41.4 ± 9.67 | 31.5 ± 7.57 | 38.5 ± 10.1 | 7.044, 0.030 | 1.806, 0.075 |
| Tryptophan [µmol/L] | 49.5 ± 10.5 | 55.8 ± 17.7 | 43.8 ± 9.54 | 52.2 ± 16.4 | 2.603, n.s. | 0.058, n.s. |
| Kynurenine [µmol/L] | 2.76 ± 1.48 | 1.92 ± 0.55 | 1.41 ± 0.44 | 1.77 ± 0.55 | 5.627, 0.060 | 1.748, 0.086 |
| Kyn/Trp [µmol/mmol] | 56.4 ± 33.7 | 35.7 ± 10.9 | 31.9 ± 4.52 | 33.7 ± 9.50 | 6.218, <0.05 | 2.447, 0.014 |
| Nitrite [µmol/L] | 6.58 ± 5.16 | 10.6 ± 16.7 | 14.32 ± 15.3 | 8.17 ± 10.1 | 0.916, n.s. | 0.233, n.s. |
| Neopterin [nmol/L] | 10.1 ± 14.8 | 6.96 ± 4.30 | 5.28 ± 1.53 | 6.47 ± 3.73 | 0.805, n.s. | 0.175, n.s. |
* p-values, comparison of C/C, C/T and T/T groups, Kruskal Wallis test; ** p-values, comparison of C/C vs. non-C/C groups, Mann Whitney U-test/.