Skip to main content
. 2015 Mar 31;7(2):585–597. doi: 10.3390/cancers7020585

Table 1.

Summary of illustrative findings related to invasiveness from gene-expression profiling studies in HNSCC.

Reference(s) Function Sense of Regulation in HNSCC Gene(s)
Ye et al. [65];
Nagata et al. [66];
Kainuma et al. [67];
Kondoh et al. [68];
Choi and Chen [69]		 Digestion and remodeling of ECM graphic file with name cancers-07-00585-i001.jpg MMP-1
MMP-3
MMP-9
MMP-10
MMP-13
MMP-2
uPA
ITGA3
ITGA5
Ye et al. [65];
Gottschlich et al. [70]		 Chemotaxis Lymphocyte activation graphic file with name cancers-07-00585-i001.jpg IL-8
CXCL1
CD28
CD3D
CD4
IL-18
IL-2
Kondoh et al. [68];
Yu et al. [53]		 Antigen presentation graphic file with name cancers-07-00585-i002.jpg MHC-I
MHC-II
Gottschlich et al. [70];
Yu et al. [71]		 Angiogenesis graphic file with name cancers-07-00585-i001.jpg VEGF signaling
IL-8
Gottschlich et al. [70];
Sun et al. [39]		 Signal transduction graphic file with name cancers-07-00585-i001.jpg EGFR
STAT-3
PI3K
NOTCH

Abbreviations: Inline graphic—Up-regulation; Inline graphic—Down-regulation; MMP—Matrix metalloproteinase; ITGA—Integrin alpha; MHC—Major histocompatibility complex; VEGF—Vascular endothelial growth factor; IL-8—Interleukin-8; CXCL1—Chemokine (C-X-C motif) ligand 1.