Table 2.

An overview on the role of [Ca²⁺]_i in neuroblastoma.

[Ca2+]i in Neuroblastoma
[Ca2+]i interacts with the growth factor signaling cascade in neuroblastoma.
Three main kinases involved in cell survival signaling in neuroblastoma include PI3K/AKT, ALK and FAK.
[Ca2+]i activated CAM kinases activates ERK1/2 exerts its role in neuroblastoma differentiation.
[Ca2+]i regulated apoptosis in neuroblastoma involves the intrinsic pathway and the activation of CaSR.
Chemotherapeutic drug treatment shows an increase in [Ca2+]i concentrations.