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. 2015 May 22;7(2):823–848. doi: 10.3390/cancers7020811

Table 3.

Increase of [Ca2+]i in human neuroblastoma cell lines: Color code in the table illustrates different receptors that initiates an increase of [Ca2+]i in neuroblastoma cell lines of human origin. Two main categories of receptors mentioned include the G-protein coupled receptor and Sigma receptors (subtypes were not differentiated).

Sl.No Cell Lines Orgin Treatment Receptor Concentration Ca2+ Release Basal [Ca2+]i Increased [Ca2+]i Reference
1 IMR-32 H Orexin-A (GPCR) Orexin Type 1 Receptor (GPCR) 3 nM Store Release (IP3R) 50 nM 4 fold [24]
2 SH-SY5Y H Retinoic Acid Retinoid X receptor (Nuclear Receptors) 10 µM Store Release 98 nM No increase [25]
3 SH-SY5Y H Retinoic Acid Retinoid X receptor (Nuclear Receptors) 1 µM Store Operated calcium Channel 10 nM 4 fold [26]
4 SH-SY5Y H Oxotremorine-M Muscarinic Receptor (GPCR) 10 µM Store Release (IP3R) 50 nM 2 fold [27]
5 SH-SY5Y H Methacholine Muscarinic Receptor (GPCR) 1 mM Store Release (IP3R) 98 nM 2 fold [25]
6 SH-SY5Y H Carbachol Muscarinic Receptor (GPCR) 1 mM Store Release - 3.5 fold [28]
7 SK-N-SH H Carbachol Muscarinic Receptor (GPCR) 100 µM Store Release 59 nM 2 fold [29]
8 SH-SY5Y H Bradykinin Bradykinin Receptor (GPCR) 10 µM Store Release (IP3R) 98 nM 1 fold [25]
9 SH-SY5Y H Bradykinin Bradykinin Receptor (GPCR) 10 µM Store Release - 2 fold [28]
10 SH-SY5Y H Arsenic Trioxide - 1 µM Store Release (IP3R and RyR) 75 nM 2 fold [31]
11 SH-SY5Y H Arsenic Trioxide - 1 µM Store Release (IP3R and RyR) 70 nM 3 fold [32]
12 SH-SY5Y H Trimethyltin Chloride - 0.1 µM Store Release - 2 fold [33]
13 SH-SY5Y H Cisplatin - 1 µM Extracellular Space 75 nM 2 fold [31]
14 SK-N-SH H CB-64D Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 4 fold [30]
15 SK-N-SH H JL-II-147 Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 2 fold [30]
16 SK-N-SH H BD737 Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 1 fold [30]
17 SK-N-SH H LR172 Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 1 fold [30]
18 SK-N-SH H BD1008 Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 1 fold [30]
19 SK-N-SH H Haloperidol Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 1 fold [30]
20 SK-N-SH H Ibogaine Sigma 2 receptor 100 µM Thapsigargin insensitive calcium store - 1 fold [30]