Table 4.

Different stages in the development of neuroblastoma.

Stage of Neuroblastoma	Tumour Characteristics	Treatment Protocol
Stage 1 (Low)	Single site specific	Surgery
Stage 2A (Low)	Single site specific and could not be removed completely by surgery.	Surgery and Chemotherapy
Stage 2B (Low)	Single site specific and could be removed completely by surgery. Cancer development could be present at lymph nodes around the tumour.	Surgery
Stage 3 (Intermediate Risk)	Cancer could be present in one or both sides of the body and lymph nodes.	Chemotherapy
Stage 4 (High Risk)	Cancer spread to distant body parts (bone, liver, skin, bone marrow and other organs) and distant lymph nodes.	Surgery, Chemotherapy, Radiotherapy, Immunotherapy and Retinoid Therapy
Stage 4S (High Risk)	Child is younger than 12 months with cancer spread on one side of the body. Lymph nodes on the same side of the body also affected.	Surgery, Chemotherapy and Radiotherapy
Relapsed/Recurrent	-	Chemotherapy, Immunotherapy, Retinoid Therapy, Tyrosine kinase and Aurora kinase inhibitors and targeted delivery of radionuclides.