Table 2.
Chest wall and related toxicity characteristics.
Toxicity | Incidence | Timing | Dosimetric Correlates | Study | ||
---|---|---|---|---|---|---|
Volume | Dose | Fraction | ||||
Chest Wall Pain | 30% risk (Range: 10% to 44%) | 12.6 months post-SBRT (Range: 4.3–35.9 months) | 30 cc of chest wall | 30 Gy | 3 (Range:3–5) | Dunlap et al., 2010 [89] Mutter et al., 2012 [84] Creach et al., 2012 [87] |
Rib Fracture | 5% risk | 19.2 months post-SBRT | 2 cc of rib | 27 Gy | 3 | Pettersson et al., 2009 [88] |
50% risk | 2 cc of rib | 50 Gy | 3 | Creach et al., 2012 [87] | ||
Skin Toxicity | 1.2%–14% | 3–6 weeks post-SBRT | <10 cc volume, volume maximum of 30 Gy | 6 Gy/fraction | 5 | RTOG 0813 [91] Hoppe et al., 2008 [92] |
maximum point dose of 32 Gy, maximum posterior skin dose ≥50% of actual prescribed dose | 6.4 Gy/fraction | 5 |