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. 2015 Jun 19;47(6):e169. doi: 10.1038/emm.2015.32

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Copyright © 2015 KSBMB.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Molecular modeling of Cx26 mutants was performed with 2ZW3 crystal structure template. (a) R75 in Cx26-WT interacts with E47, S82 and E187. (b) R75Q in Cx26-R75Q has only hydrogen bond with S82. (c) The distance of hydrogen bond between R75Q and S82 is farther away and the axis and torsional angle of E47 and E187 are affected by the addition of V37I mutation in Cx26-R75Q.