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. 2015 Jun 15;112(26):8070–8075. doi: 10.1073/pnas.1424355112

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Fig. S2. — Expression of PGD synthases and 15-PGDH in human neuroblastoma (NB) tumors. (A) IHC analysis of H-PGDS, L-PGDS, and 15-PGDH in primary human neuroblastoma tumors with different biology: MYCN-amplification (NB1), 11q-deletion (NB2 and NB12), and low-risk (NB4). Sections were counterstained with Mayer’s hematoxylin. One representative image selected from the staining of at least three tumors from each neuroblastoma subtype is shown. (B) Sections from three tumors in each subgroup were quantified. Significantly higher levels of L-PGDS were found in low-risk tumors than in 11q-deleted tumors (P = 6.0e-04). H-PGDS was expressed at higher levels in MYCN-amplified (P = 0.02) and low-risk tumors (P = 0.03) than in 11q-deleted tumors. Also, 15-PGDH was expressed at higher levels in low-risk tumors than in 11q-deleted tumors (P = 0.004). Data are represented as mean ± SEM.