Figure 2.
Gene expression of liver and adipose tissue, and immunohistochemistry of adipose tissue. (a) Liver gene expression showed decreased expression of Tnf-α and Ccl2 (n=8). (b) Adipose tissue showed no changes in the expression of these two genes, (c) but adiponectin expression was reduced in mice treated with the HMGB1 antibody (n=8). (d) Immunohistochemistry staining for macrophages in adipose tissue did not differ between the two groups (n=4; *P<0.05, **P<0.01).