Table 3. Correlations between bacterial species and lipid metabolism with and without covariate adjustment.
| Species | TAG | Cholesterol | HDL-C | LDL-C |
|---|---|---|---|---|
| Associated with a healthy lipid metabolism | ||||
| Akkermansia muciniphila | −0.17 (0.120) | −0.42 (0.002) | 0.14 (0.826) | −0.37 (0.005) |
| Adj. (age and body fat) | −0.32 (0.091) | −0.39 (0.002) | 0.17 (0.886) | −0.33 (0.006) |
| Adj. (diet) | −0.17 (0.195) | −0.40 (0.002) | 0.21 (0.900) | −0.34 (0.007) |
| Adj. (full model) | −0.32 (0.156) | −0.37 (0.002) | 0.07 (0.926) | −0.29 (0.008) |
| Bacteroides cellulosilyticus | −0.37 (0.004) | −0.48 (<0.001) | −0.13 (0.781) | −0.38 (0.003) |
| Adj. (age and body fat) | −0.45 (0.002) | −0.48 (<0.001) | −0.11 (0.883) | −0.37 (0.002) |
| Adj. (diet) | −0.36 (0.007) | −0.47 (<0.001) | −0.19 (0.748) | −0.38 (0.007) |
| Adj. (full model) | −0.43 (0.003) | −0.46 (<0.001) | −0.11 (0.875) | −0.36 (0.005) |
| Bacteroides nordii | −0.24 (0.050) | −0.50 (<0.001) | 0.09 (0.458) | −0.46 (<0.001) |
| Adj. (age and body fat) | −0.30 (0.049) | −0.48 (<0.001) | 0.10 (0.437) | −0.44 (<0.001) |
| Bacteroides pectinophilus | −0.42 (0.001) | −0.42 (0.001) | 0.12 (0.199) | −0.47 (<0.001) |
| Adj. (age and body fat) | −0.53 (<0.001) | −0.41 (<0.001) | 0.25 (0.128) | −0.46 (<0.001) |
| Adj. (diet) | −0.42 (0.002) | −0.40 (0.002) | 0.05 (0.167) | −0.45 (<0.001) |
| Adj. (full model) | −0.52 (<0.001) | −0.39 (0.001) | 0.23 (0.100) | −0.45 (<0.001) |
| Odoribacter splanchnicus | −0.48 (<0.001) | −0.30 (0.016) | 0.12 (0.596) | −0.21 (0.072) |
| Adj. (age and body fat) | −0.53 (<0.001) | −0.26 (0.019) | 0.17 (0.346) | −0.17 (0.058) |
| Roseburia inulinivorans | −0.24 (0.044) | −0.43 (<0.001) | −0.14 (0.801) | −0.35 (0.006) |
| Adj. (age and body fat) | −0.31 (0.040) | −0.41 (0.001) | −0.11 (0.977) | −0.33 (0.005) |
| Associated with an unhealthy lipid metabolism | ||||
| Catenibacterium mitsuokai | 0.16 (0.746) | 0.45 (0.004) | −0.17 (0.986) | 0.43 (0.005) |
| Adj. (age and body fat) | 0.04 (0.639) | 0.39 (0.007) | −0.09 (0.805) | 0.37 (0.008) |
| Adj. (diet) | 0.17 (0.898) | 0.43 (0.008) | −0.24 (0.817) | 0.42 (0.010) |
| Adj. (full model) | 0.06 (0.747) | 0.36 (0.012) | −0.19 (0.706) | 0.35 (0.012) |
| Holdemanella biformis | 0.27 (0.030) | 0.49 (<0.001) | 0.14 (0.935) | 0.44 (<0.001) |
| Adj. (age and body fat) | 0.27 (0.082) | 0.46 (<0.001) | 0.12 (0.779) | 0.41 (<0.001) |
| Adj. (diet) | 0.28 (0.099) | 0.49 (<0.001) | 0.18 (0.960) | 0.43 (0.003) |
| Adj. (full model) | 0.27 (0.183) | 0.46 (<0.001) | 0.06 (0.762) | 0.40 (0.003) |
Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TAG, triglycerides. Correlations are presented as Pearson's r with P-values in parentheses, with and without adjustment (adj.) for age, body fat, and when relevant; the dietary component with the strongest impact (Supplementary Table S4). Full models are adjusted for age, body fat and diet.