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. 2015 Jul 7;16:98. doi: 10.1186/s12882-015-0100-y

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© Kalim et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Comparison of metabolite profiles across tertile of body mass index (BMI). Study subjects were grouped by BMI tertile (tertile 1 = lowest BMI). Left: Partial least squares discriminant analysis (PLS-DA) score plot for the study population separated by phenotype class. Oval outlines denote 95 % confidence intervals. Right: The variable importance in projection (VIP) scores for the 15 metabolites with the greatest score. The colored boxes on the right indicate the direction of metabolite alterations across phenotype tertile. Abbreviations: BAIBA, β-aminoisobutyric acid; SDMA, symmetric dimethylarginine; 3-PG, 3-phosphoglycerate; b-OH-butyrate, β-hydroxybutryate; p-creatine, phosphocreatine; XMP, Xanthosine-5-phosphate