Table 5.
Cross sectional analysis of albumin tertiles and select metabolites
| 1 | 2 | 3 | P | |
|---|---|---|---|---|
| kynurenine | 425 998 (298 054, 535 460) | 478 927 (395 468, 596 735) | 552 251 (433 248, 679 481) | 1.8E-4* |
| tryptophan | 273 066 (223 467, 413 194) | 315 338 (255 914, 423 927) | 393 551 (301 885, 501 066) | 2.5E-4* |
| creatine | 2 157 292 (1 397 576, 3 355 087) | 1 907 461 (1 145 455, 2 791 140) | 1 570 693 (1 182 023, 2 037 120) | 4.9E-3 |
| indoxylsulfate | 42 510 713 (24 175 943, 58 375 318) | 55 564 881 (34 527 474, 67 400 369) | 57 398 073 (33 359 446, 80 148 935) | 1.3E-2 |
| 12:0 carnitine | 28 261 (18 195, 40 622) | 30 496 (18 540, 44 940) | 36 915 (24 245, 50 553) | 2.7E-2 |
| aspartate | 36 448 (25 083, 49 840) | 34 626 (24 685, 48 518) | 26 533 (20 120, 36 067) | 1.9E-3 |
| thyroxine | 2 332 (1 929, 2 738) | 2 523 (1 879, 2 916) | 2 712 (2 115, 3 244) | 1.8E-2 |
| indolelactate | 12 722 (8 573, 19 334) | 15 627 (11 171, 22 311) | 16 269 (11 922, 22 700) | 3.6E-2 |
| BAIBA | 46 979 (27 423, 106 593) | 42 313 (24 146, 80 713) | 34 051 (23 583, 57 272) | 1.0E-1 |
| alanine | 1 280 822 (985 715, 1 604 978) | 1 249 845 (1 028 428, 1 494 869) | 1 337 859 (1 117 636, 1 758 661) | 6.9E-2 |
| 10:0 carnitine | 33 566 (21 210, 61 857) | 48 413 (25 775, 68 324) | 47 884 (31 469, 72 628) | 5.8E-2 |
| SDMA | 896 522 (765 176, 1 090 288) | 925 219 (772 578, 1 063 241) | 824 248 (730 601, 974 498) | 5.2E-2 |
| hydroxyproline | 235 578 (162 155, 374 510) | 203 966 (149 720, 306 721) | 198 496 (150 564, 259 207) | 1.5E-1 |
| GCDCAs | 487 186 (203 751, 773 938) | 421 065 (248 114, 748 019) | 715 307 (356 712, 1 064 255) | 1.4E-2 |
| ADP | 280 998 (155 075, 610 214) | 539 330 (278 012, 877 605) | 455 070 (164 681, 1 239 020) | 1.2E-2 |
Values are median peak area for the metabolites (quartile 1, quartile 3)
*P-value significant at the Bonferroni adjusted level of 3.0 × 10−4