Table 6.
Cross sectional analysis of total cholesterol tertiles and select metabolites
| 1 | 2 | 3 | P | |
|---|---|---|---|---|
| tryptophan | 440 068 (345 130, 586637) | 323192 (257580, 429806) | 274624 (223120, 324798) | 1.7E-9* |
| 18:2 carnitine | 60 494 (38 250, 107 981) | 49 737 (27 163, 73 344) | 32 084 (19 167, 53 863) | 9.0E-7* |
| 18:1 carnitine | 88 418 (58 090, 144 102) | 69 442 (40 568, 103 682) | 47 134 (33 127, 74 763) | 6.0E-7* |
| 18:0 carnitine | 12 789 (10 118, 18 240) | 10 879 (7 872, 14 622) | 8 466 (6 103, 12 433) | 7.7E-5* |
| arginine | 175 576 (136 362, 259 524) | 187 566 (132 389, 324 585) | 321 420 (216 851, 491 848) | 9.6E-6* |
| 10:0 carnitine | 52 498 (28 731, 92 694) | 40 556 (26 190, 67 085) | 34 244 (20 094, 52 420) | 7.0E-3 |
| glycocholate | 193 580 (60 425, 672 001) | 105 938 (61 765, 208 013) | 76 985 (42 135, 222 324) | 5.6E-3 |
| taurocholate | 128 124 (30 180, 379 765) | 91 894 (35 067, 188 948) | 47 535 (24 706, 128 025) | 1.9E-2 |
| GMP | 640 409 (341 616, 884 723) | 544 860 (409 493, 969 998) | 831 864 (565 936, 1 246 583) | 8.9E-3 |
| AMP | 2 898 935 (2 275 762, 3 795 325) | 3 153 490 (2 679 559, 4 251 281) | 3 708 724 (3 046 005, 4 670 016) | 1.6E-3 |
| carnosine | 23 811 (15 639, 77 524) | 34 287 (14 160, 119 781) | 64 617 (29 846, 195 284) | 6.5E-3 |
| aminoadipate | 139 402 (119 264, 184 086) | 167 760 (130 029, 210 530) | 186 821 (144 705, 242 940) | 3.3E-3 |
| 16:1 carnitine | 68 049 (46 259, 99 787) | 65 354 (35 653, 77 665) | 49 527 (39 008, 71 026) | 2.1E-2 |
| 14:0 carnitine | 9 893 (6 819, 17 108) | 8 969 (5 659, 12 834) | 7 848 (5 373, 10 960) | 3.1E-2 |
| p-creatine | 42 102 (30 390, 51 406) | 46 713 (36 982, 55 510) | 50 600 (37 472, 70 045) | 1.8E-2 |
Values are median peak area for the metabolites (quartile 1, quartile 3)
*P-value significant at the Bonferroni adjusted level of 3.0 × 10−4