Fig. 1.

Comparative miRNA profiling in non-metastatic primary xenografts and the manifold of metastatic tumors from animals bearing aggressive neuroblastoma. a Representative mice showing non-metastatic xenograft and high-risk aggressive metastatic disease. Plate showing tumors harvested from multiple metastatic sites. b Schematic representation showing relative tumorigenic capacity and aggressive disease formation of parental SH-SY5Y and metastatic site derived aggressive cells (MSDACs). Subcutaneously injecting MSDACs produced large xenograft with multiple metastatic tumors in retroperitoneal, pelvic, abdominal, and chest cavities. c Traverse analysis of whole genome miRNA expression between non-metastatic (X-NB) and aggressive disease (AD) animals. Total of 852 miRNAs were compared between groups and their alterations are color coded (Red – upregulated; Blue – down regulated). Total number of altered molecules under each comparison is provided in the corresponding box. Numbers in the parenthesis are the molecules that are significantly (> or < 2 fold) modulated