Fig. 3.

Regulated miRNAs in high-risk metastatic neuroblastoma. a Histograms showing the expression profile of 22 miRNAs that were significantly (<2 fold) down regulated across the metastatic tumors of the animals with aggressive disease. Data mining was performed using traverse analysis comparing each non-metastatic control to that of the aggressive disease profiles. b miRNA RT-qPCR analysis showing the complete regulation of Hsa-miR-93, Hsa-miR-20a, Hsa-miR-125b and Hsa-miR-27b and, significant increase in the expression of Hsa-miR-1260 and Hsa-miR-1224-3p in metastatic tumors as compared to the non-metastatic xenograft