Table 1.
Targets analyzed by the western-blot and the expression status (color coded) of the corresponding metastamiRs in high-risk metastatic neuroblastoma
| ADAMTS-1 | miR-1224-3p, miR-1260, miR-125b |
| ASK1 | miR-1258, miR-1243, miR-519c-3p, miR-1224-5p, miR-20a, miR-93, miR-1260, miR-23a*, miR-30b* |
| AURK ß | miR-765 |
| BIRC2 | miR-500* |
| cMYC | let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98 |
| CASP8 | miR-519c-3p, miR-143*, miR-20a, miR-93, miR-1224-3p |
| CD1C | miR-1306, miR-190, miR-190b, miR-620 |
| CD54 | miR-431* |
| CDK4 | miR-548m, miR-765 |
| CFOS | miR-383 |
| PARP | miR-519c-3p, miR-766 |
| CREB | miR-190, miR-190b, miR-1224-5p, miR-20a, miR-93, miR-125b, miR-27b |
| CTGF | miR-30c-1*, miR-576-3p, miR-383, miR-143*, miR-30b* |
| CXCR4 | miR-1, miR-206 |
| CYCLIN D1 | let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-383, miR-1269, miR-1, miR-206, miR-20a, miR-93, miR-23a*, miR-608 |
| EGFR | miR-664*, miR-1250, miR-1269, miR-1, miR-206, miR-149*, miR-27b, miR-1909*, miR-608 |
| ELK1 | miR-1260, miR-125b, miR-765, miR-1321, miR-608 |
| NOS3 | miR-887, miR-1244, miR-765 |
| ESR1 | miR-188-5p, miR-190, miR-190b, miR-1182, miR-519c-3p, miR-1, miR-206, miR-148b, miR-20a, miR-93, miR-1909* |
| E-SELECTIN | miR-593 |
| FOS B | miR-766, miR-1, miR-206, miR-148b, miR-1224-3p, miR-1260, miR-23a*, miR-765, miR-27b, miR-1909*, miR-608 |
| FRA | miR-593, miR-149* |
| GRB10 | miR-519c-3p, miR-513a-5p, miR-30b*, miR-125b |
| IL-1α | miR-149*, miR-30b* |
| JUN D | miR-1, miR-206, miR-1321 |
| kRAS | let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-1243, miR-143*, miR-513a-5p, miR-1, miR-206, miR-200b, miR-30b*, miR-27b |
| KRTAP1-1 | miR-601, miR-1258, miR-143*, miR-23a* |
| MCP1 | miR-664*, miR-593 , miR-1, miR-206 |
| MEGF10 | miR-190, miR-190b, miR-1258, miR-383 |
| MMP10 | miR-32*, miR-32, miR-367*, miR-148b |
| MMP2 | miR-20a, miR-93, miR-765, miR-125b, miR-1321, miR-608 |
| MMP3 | miR-20a, miR-93 |
| MTA2 | miR-148b, miR-1321 |
| MYB | miR-1224-5p |
| NF2 | miR-1909*, miR-32*, miR-32, miR-367*, miR-608 |
| GSK3B | miR-624*, miR-1, miR-206, miR-23a*, miR-27b |
| P38 | miR-1258, miR-1243, miR-513a-5p, miR-125b, miR-27b |
| P21 | miR-92a-2*, miR-32*, miR-32, miR-367*, miR-20a, miR-93, miR-765, miR-608 |
| AKT2 | miR-200b, miR-148b, miR-1224-3p, miR-1260, miR-1909*, miR-608 |
| AKT3 | miR-320b, miR-320c, miR-149*, miR-20a, miR-93 |
| PKC | miR-30b*, miR-1321, miR-1909* |
| PTPN3 | miR-593, miR-20a, miR-93, miR-765, miR-27b |
| SDF-1ß | miR-624*, miR-1182, miR-519c-3p, miR-1260, miR-23a*, miR-765, miR-1909* |
| SEMA3D | miR-432, miR-1268, miR-1321 |
| STAT3 | let-7a, let-7b, let-7c, let-7e, let-7f, let-7g, miR-98, miR-1244, miR-20a, miR-93, miR-125b, miR-1909*, miR-608 |
| SURVIVIN | miR-1182, miR-1321 |
| TNFR1 | miR-766 |
| TNF-α | miR-125b-1*, miR-519c-3p, miR-1909* |
| VEGF | miR-383, miR-1, miR-206, miR-200b, miR-20a, miR-125b, miR-27b |
Up regulated; Down Regulated