Table 5.
Cumulative effects of familial history of hepatitis B virus on hepatitis B virus infection
| Variables | HBsAg negative | HBsAg positive | OR (95%CI) | P value |
| Mother | 1031 | 317 | 3.57 (3.12-4.08) | < 0.001 |
| Father | 2488 | 432 | 1.95 (1.75-2.17) | < 0.001 |
| Spouse (≥ 20 yr) | 3363 | 531 | 1.02 (1.00-1.04) | 0.041 |
| Offspring (≥ 20 yr) | 1817 | 283 | 1.61 (1.41-1.83) | < 0.001 |
| Siblings | 1059 | 353 | 3.10 (2.73-3.51) | < 0.001 |
| Other families | 1061 | 130 | 1.57 (1.30-1.89) | < 0.001 |
| Combined familial history of HBV and HBV infection | ||||
| 0 | 123472 (92.29) | 9525 (84.88) | 1 | - |
| 1 | 9838 (7.36) | 1562 (13.95) | 1.93 (1.82-2.05) | < 0.001 |
| 2 | 462 (0.34) | 121 (1.05) | 3.19 (2.60-3.92) | < 0.001 |
| 3-6 | 19 (0.01) | 14 (0.12) | 9.82 (4.80-20.11) | < 0.001 |
| Trend | < 0.0011 | |||
| 0 | 123472 (92.29) | 9525 (84.88) | 1 | - |
| 1-6 | 10319 (7.71) | 1697 (15.12) | 2.00 (1.89-2.12) | < 0.001 |
1
The P value of Cochran-Armitage’s trend test. Logistic regression analyses adjusted for age, sex, and immunization history of HBV.