Table 3.

Subgroup analysis on diagnostic performance of magnifying endoscopy with narrow-band imaging for differentiating early gastric cancer from non-cancer

	Number of studies (lesions examined)	Sensitivity (95%CI)	Specificity (95%CI)	AUC	I2
					Sensitivity	Specificity
Overall	14 (2433)	0.86 (0.83-0.89)	0.96 (0.95-0.97)	0.9623	75.4%	86.9%
Type of lesion
Depressed	3 (605)	0.64 (0.52-0.75)	0.96 (0.95-0.98)	0.7877	0.0%	74.1%
Not depressed	10 (1828)	0.90 (0.86-0.92)	0.96 (0.95-0.97)	0.9694	64.9%	90.1%
Diagnosis standard
Diagnosis (IMVP/IMSP + DL)	7 (1613)	0.81 (0.76-0.85)	0.97 (0.96-0.98)	0.9407	78.0%	88.8%
Diagnosis (others)	7 (820)	0.93 (0.89-0.96)	0.93 (0.91-0.95)	0.9719	36.6%	80.5%
Lesion size
Diameter (> 10 mm)	8 (777)	0.90 (0.86-0.93)	0.88 (0.85-0.91)	0.9585	71.2%	44.7%
Diameter (≤ 10 mm)	5 (1449)	0.74 (0.65-0.82)	0.98 (0.97-0.98)	0.9458	67.1%	86.6%
Sample size
≥ 100 patients	8 (2035)	0.84 (0.79-0.88)	0.97 (0.96-0.97)	0.9663	79.1%	90.7%
< 100 patients	6 (398)	0.90 (0.85-0.93)	0.87 (0.81-0.92)	0.9422	67.3%	0.0%
Type of assessment
Real-time	8 (1310)	0.85 (0.81-0.90)	0.95 (0.94-0.96)	0.9617	81.6%	81.2%
Post-procedure	6 (1123)	0.87 (0.82-0.91)	0.97 (0.95-0.98)	0.9608	65.5%	91.6%
Country
China	3 (1014)	0.94 (0.88-0.97)	0.98 (0.97-0.99)	0.9864	62.5%	95.7%
Japan	11 (1419)	0.84 (0.80-0.88)	0.94 (0.92-0.95)	0.9526	74.6%	71.2%

I² > 50% was considered significant for heterogeneity. AUC: Area under the curve.