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Effect of the combination of rapamycin and resveratrol on the PI3K/Akt/mTORC1 signaling pathway. Inhibition of mTORC1 by rapamycin induces autophagy, activates Akt signaling and promotes cell survival. Addition of resveratrol treatment prevents rapamycin-induced Akt activation and autophagy induction, promoting the progression to apoptosis.
