Figure 2.

Chromatin components and modifiers affecting reprogramming efficiency

Reprogramming requires the establishment of permissive chromatin and is associated with chromatin opening and changes to histone and DNA modifications. Multiple factors have been implicated in these processes: marked in green and red are factors whose presence/activity is associated with increased and decreased reprogramming efficiency, respectively; marked in purple are those factors whose presence/activity has been shown to both increase and decrease reprogramming efficiency in a context-dependent manner; factors whose influence on reprogramming requires further investigation are marked by (?).