Figure 3.

Musashi RBP expression during spermatogenesis. dMsi paralogs dMsi and Rbp6 are differentially expressed in the fly testis: dMsi is nuclear and expressed in early germ cells and spermatocytes while Rbp6 is cytoplasmic and localized to spermatogonial cyst cells. Mammalian Msi1 is expressed in the cytoplasm of early mitotic germ cells before translocating to the nucleus upon transition to meiosis. Mammalian Msi2 is entirely nuclear, expressed throughout meiosis and during spermatid differentiation. The dotted line refers to cytoplasmic localization while the solid line refers to nuclear-specific expression. RBP: RNA binding proteins; Msi1: Musashi-1; Msi2: Musashi-2; dMsi: Drosophila Musashi; Rbp6: RNA-binding protein 6.