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Inactivation of gelsolin by Src-dependent tyrosine phosphorylation: the tyrosine kinase Src is activated by the HCO3−/sAC/cAMP/PKA system leading to gelsolin phosphorylation on Tyr-483 which is stimulated by gelsolin binding to PIP2. Under these conditions p-gelsolin is inactive and actin polymerization occurs.
