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. 2015 Jul 7;13:216. doi: 10.1186/s12967-015-0586-x

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© Kober et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Injection of VACV into mouse brain tissues with and without implanted gliomas. a C57BL/6 and Foxn1^nu/nu mice with (w) and without (w/o) GL261 brain tumors were infected with 5 × 10⁶ pfu LIVP 1.1.1 (i.t). For analysis of viral titers, brains were excised 1, 3 and 7 days after virus injection and analyzed by standard plaque assay [n = 4/5 per group (w) and n = 3 per group (w/o) tumor]. All samples were measured in duplicate (data are mean values ± SD; t test *p < 0.05). b Immunohistochemical staining for astrocytes (anti-GFAP, red) and VACV (anti-VACV, green) 1 dpi in GL261 implanted tumors. Shown are representative examples.