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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Mol Cell Cardiol. 2012 Aug 19;53(5):668–676. doi: 10.1016/j.yjmcc.2012.08.010

Fig. 4.

Fig. 4

Transrenal release of exosome-carried miRNAs. (A)–(C) The miR-1 levels in liver, spleen and kidney of Sham-opened rats and of the rats at 24 h after AMI. (D) Representative serum exosomes isolated by ultracentrifugation and detected by electron microscopy. (E) miR-1 levels in serum exosomes from normal rats and from rats with AMI. (F) miR-1 levels in freshly isolated exosomes of AMI serum and in these exosomes kept for 24 h at 4 °C. G. Administration of the serum exosomes from rats with AMI to aortas of normal rats resulted in the time-dependent increase in urine miR-1. H. Comparison of urine miR-1 levels exosomes-treated rats between the delivery via aortas and the delivery via external jugular veins. Note: n=5, *P<0.05 compared with the control group.