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. Author manuscript; available in PMC: 2015 Jul 6.
Published in final edited form as: J Mol Cell Cardiol. 2012 Aug 19;53(5):668–676. doi: 10.1016/j.yjmcc.2012.08.010

Fig. 6.

Fig. 6

Transrenal release of exosomes. PKH67-labeled exosomes or unlabeled exosomes were injected into circulating blood of rats. The urine exosomes from these rats were isolated and were added to the culture medium of HEK293 cells to detect to PKH67-labeled exosomes in cells. HEK293 cells cultured with vehicle are used as a negative control and HEK293 cells cultured directly with PKH67-labeled exosomes were used as a positive control. Fluorescence signal (green color) was detected by a fluorescence microscopy. (A) Negative control. (B) Cells cultured with urine exosomes from unlabeled exosomes-injected animals. (C) Cells cultured with urine exosomes from PKH67-labeled exosomes-injected animals. (D) Positive control.