Table 1.

Biodistribution of carboplatin in F98 glioma bearing rats following i.v. injection or CED

	Carboplatin concentrations (μg/gm ± SD)
Group	Tumor	Blood	Brain (R)	Brain (L)	Kidney	Liver
25 mg/kg b.w./i.v.	4.1±1.2	3.3±0.7	8.4±3.5	3.5±4.6	63.9±43.6	23.3±14.2
100 mg/kg b.w./i.v.	9.8±1.9	25.7±8.7	11.3±6.7	7.2±3.2	424.6±152.7	44.7±17.4
20 μg/CED	10.4±2.7	<0.01	1.2±0.2	0.8±0.2	<0.01	<0.01

^a 10⁵ F98 glioma cells were implanted into the right caudate nucleus of Fischer rats. Twelve -14 days later, rats received an i.v. injection of carboplatin and were euthanized 2.5 h later. Alternatively, 20 μg of carboplatin was administered i.c. by CED in a volume of 10 μL for 30 min at a flow rate of 0.33 μL/min.

Following termination of the infusion, they were immediately euthanized, and the tumors and normal tissues were collected for platinum concentrations and carboplatin were determined by ICP-OES and based on these values, the drug concentrations were calculated.