Fig. 8.
DNA methylation around transcriptional start sites. Around gene start sites, and persisting into the first 500 base pairs of the gene body, we observe a significant drop in DNA methylation. For CG (p-value = 6.45 × 10−55), CHG (p = 3.38 × 10−100), and CHH (p = 4.61 × 10−308) methylation was significantly reduced in the first 500bp of the gene relative to the up-stream regions. Both CG (p = 3.55 × 10−138) and CHG (p = 4.04 × 10−11) methylation then significantly increases over the next 500 bp, while for CHH it continued to decline (p = 8.93 × 10−10)